Browsing by Author "Berglin, Mattias"

Now showing items 1-3 of 3

    • Anti-Colonization Effect of Au Surfaces with Self-Assembled Molecular Monolayers Functionalized with Antimicrobial Peptides on S. epidermidis 

      Karlsen, Eskil André; Stensen, Wenche; Juskewitz, Eric; Svenson, Johan; Berglin, Mattias; Svendsen, John Sigurd Mjøen (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-10)
      Medical devices with an effective anti-colonization surface are important tools for combatting healthcare-associated infections. Here, we investigated the anti-colonization efficacy of antimicrobial peptides covalently attached to a gold model surface. The gold surface was modified by a self-assembled polyethylene glycol monolayer with an acetylene terminus. The peptides were covalently connected ...

    • Flexible and Biocompatible Antifouling Polyurethane Surfaces Incorporating Tethered Antimicrobial Peptides through Click Reactions 

      Berglin, Mattias; Cavanagh, Jorunn Pauline; Caous, Josefin Seth; Thakkar, Balmukund; Vasquez, Jeddah Marie; Stensen, Wenche Gunvor B; Lyvén, Benny; Svendsen, John Sigurd Mjøen; Svenson, Johan (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-27)
      Efficient, simple antibacterial materials to combat implant-associated infections are much in demand. Herein, the development of polyurethanes, both cross-linked thermoset and flexible and versatile thermoplastic, suitable for “click on demand” attachment of antibacterial compounds enabled via incorporation of an alkyne-containing diol monomer in the polymer backbone, is described. By employing ...

    • Preventing E. coli Biofilm Formation with Antimicrobial Peptide-Functionalized Surface Coatings: Recognizing the Dependence on the Bacterial Binding Mode Using Live-Cell Microscopy 

      Hansson, Adam; Karlsen, Eskil André; Stensen, Wenche Gunvor B; Svendsen, John Sigurd Mjøen; Berglin, Mattias; Lundgren, Anders (Journal article; Tidsskriftartikkel; Peer reviewed, 2024-01-31)
      Antimicrobial peptides (AMPs) can kill bacteria by destabilizing their membranes, yet translating these molecules’ properties into a covalently attached antibacterial coating is challenging. Rational design efforts are obstructed by the fact that standard microbiology methods are ill-designed for the evaluation of coatings, disclosing few details about why grafted AMPs function or do not ...